AcrAB Efflux System: Expression and Contribution to Fluoroquinolone Resistance in Klebsiella spp.

نویسندگان

  • Annarita Mazzariol
  • Jessica Zuliani
  • Giuseppe Cornaglia
  • Gian Maria Rossolini
  • Roberta Fontana
چکیده

Seven Klebsiella pneumoniae and four Klebsiella oxytoca clinical isolates with different levels of resistance to ciprofloxacin were studied. Mutations in the topoisomerase genes were found in almost all strains, but the contribution of a multidrug efflux system homologous to AcrAB in Escherichia coli was also observed. Overexpression of this efflux system was demonstrated by immunoblotting with antibodies against E. coli AcrA.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 46 12  شماره 

صفحات  -

تاریخ انتشار 2002